What if you could watch chronic wounds resume healing?
Warning: technical jargon ahead, formatted for computer screens
Note: The Instant Verification System recorded non-healing wounds as they visibly resumed healing during the first minutes of therapy. The early data suggests that, once restarted, the non-healing wounds may continue healing via the standard of care. The therapy may be repeated.
How many non-healing wounds might benefit from variable-wavelength therapy?
Pressure ulcers acquired in hospitals have good data because the "cause" of the injury is known. However, poor nutrition and overall health may be factors.
8.2M Medicare beneficiaries have at least one type of wound or infection (not pneumonia). (2)
34M in U.S. have diabetes. 11.7% report vision disability, 130,000 lower extremity amputations in 2016. (3) About 13% have diabetic foot ulcers of various types. (4)
From "Preventing Pressure Ulcers in Hospitals" - (1)
Could a few photons accelerate wound healing?
Photobiomodulation using fixed wavelengths has been shown to accelerate wound healing by reducing inflammation, increasing circulation, and antimicrobial action. However, the particular fixed wavelengths being applied might not be optimal at that moment in time.
Some bioactive molecules may respond only to precise wavelengths. The molecules that give cells their color are called chromophores which selectively absorb photons. The chromophore's selectivity means that a 10nm miss in the wavelength might result in a failure. The Vari-Chrome Pro filters out other wavelengths that may tend to cancel the stimulation.
The healing may have stalled for reasons that others may discover, such as that wounds having a layer of moist exudates, without infection, have been found to be more likely to visibly respond than super-cleaned wounds. Therefore, it may not be necessary to super-clean non-infected wounds.
Wavelength testing while developing the Vari-Chrome® Pro found that no single range of wavelengths "worked" for all wounds. Pre-programmed setting #2 (Orange - Yellow) let the practitioners see fresh reddish exudates enter moist wounds that would not have been visible in red wavelengths.
With no missing wavelengths, the Vari-Chrome Pro varying the wavelength during therapy increases the likelihood of finding wavelengths prompt improved functioning.
Could "no missing wavelengths" be the key?
The wavelengths needed by a particular wound to resume/accelerate healing at any given moment may be uncertain. Each wound may need different wavelengths as healing progresses but stalls again. There may be multiple problems, such a pain or poor circulation that might be improved via different wavelengths of photobiomodulation.
The Vari-Chrome® Pro addresses these wavelength uncertainties by sequentially presenting the wound with photons with varying properties. At any instant, the beam includes selected wavelengths while excluding other wavelengths that might compete with the stimulation.
A molecule must absorb a photon to begin a cascade of signaling. The photon deposits its quantum of energy and exists no more. The action takes less than a trillionth of a second. Then, unknown "factors" signal that it's time to resume healing.
For example, the Vari-Chrome Pro's #1pre-programmed selection varies the wavelength in the red spectrum that may be useful for reducing inflammation. The red wavelengths "penetrate" the skin to reach deeper tissues. Varying the wavelengths increases the likelihood that the molecules or cells receive the wavelengths needed.
For example, the #2 pre-programmed selection varies the wavelength over a range wherein reddish molecules in fresh exudates become visible in yellow wavelengths.
The Vari-Chrome beam varies with no missing wavelengths. This is important because the variation may sequentially stimulate different molecules.
Readers mentioned that they didn't want to see wound images without an intentional click.
Take the wound care specialist to the patient
Now patients living in at home, rural, or remote areas may have state-of-the-art wound care via telemedicine. The wound care specialist may now watch the restart of wound healing in real time. Their observations, via a smart phone link, might lead to saving limbs without the patient traveling to a specialty clinic.
Multi-spectral recordings of fresh exudates in moist wounds may confirm progress, or not. Healing may resume without an immediate visible marker.
1. Preventing Pressure Ulcers in Hospitals, page 9 https://www.ahrq.gov/sites/default/files/publications/files/putoolkit.pdf Downloaded 2021-04-03
2. Nussbaum SR, Carter MJ, Fife CE, DaVanzo J, Haught R, Nusgart M, Cartwright D. An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds. Value Health. 2018 Jan;21(1):27-32. doi: 10.1016/j.jval.2017.07.007. Epub 2017 Sep 19. PMID: 29304937. Downloaded 2021-04-03
3. National Diabetes Statistics Report 2020, CDC https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf Downloaded 2021-04-03
4. Sen CK. Human Wounds and Its Burden: An Updated Compendium of Estimates. Adv Wound Care (New Rochelle). 2019;8(2):39-48. doi:10.1089/wound.2019.0946 Downloaded 2021-04-03