What if you could watch the effects of aging reverse?

Warning: technical jargon ahead

 

Aging, like fragmentation of a hard disc, slows basic functions needed for normal operation. “Defrag” the disc and the speed of the systems resumes.

Chronic pain accelerates aging. Pain increases inflammation, weakened immune system, weakened musculoskeletal functions, and affects brain aging bio-markers. (1)

Could the back to normal function work like defragging a hard drive?

 

This stuff couldn’t happen, but it did >> and fast

For nearly 20 years, PhotoMed’s team was frustrated by its lack of a medical explanation for the crazy-fast responses. Not only did the therapy “work” for many disorders that seemed disrelated, but it happened too quickly. It didn’t make sense to us. Would it make sense to you?


PhotoMed’s team developed software and hardware systems to record what might be happening during the events. After 18 years and $14M, the system became the Instant Verification System; an integrated system of sensors, software, machine learning, and AI.

InstantVerification2019-07-23.png
 
 


Real-time recordings document improving bio-markers during the crazy-fast events. Most practitioners and patients don’t care why they got better. Just use the therapy. One day the researchers will figure it out. 

The responses happen quickly enough for the operator to make treatment decisions that improve the likelihood of patient benefit.


Bio-markers, such as abnormally cold limbs, simplify resolving associated pain and impaired functions. The operator monitors the skin temperature using thermal imaging for feedback. They can observe that warming has begun before the patient recognizes an improvement. Warming frequently predicts later pain relief from disorders such as complex region pain syndrome (CRPS or RSD) or diabetic neuropathy.

The engineers thought that warming was cool because it was easy to record and measure.

After a decade of examining warming events, their machine-learning methods suggested something special. They quickly examined old real-time recordings.

Had they known to look, the observation was obvious in the first recordings. Both hands or feet warmed irrespective of the treatment parameters. More interesting were cases where the temperature changes tracked side-to-side.

What might be going on?

PhotoMed’s neurosurgeon advisor, Robert E. Florin, M.D., speculated that this observation was important. He suggested that the bilateral responses might lead to brain imaging to find the location of the temperature control system. The synchronized warming demonstrated that the control signals emanated from before the left and right split.

Dr. Florin delighted in the thought that someday researchers might learn how normal works.

Dr. Florin examined responses and outcomes data from many CRPS patients. He suggested that photons with varying quantum properties might connect with the body in very ordinary ways. That is, the skin responds to photons of specific energies like touch pressure and other signals. The noisy signals from the array of photons might prompt the brain to look to see what might be going on. 

 

He wondered:

  • What if stuck brain maps might be perceived as painful?

  • Could the noisy signal from the photons prompt remapping as a quantum process waiting for someone to discover?

  • Could the noisy feeling in neuropathy interact with the noisy signal from the photons?

Dr. Florin’s questions were far ranging. He encouraged the engineers to develop software and hardware that could provide ever finer details for future researchers to nibble on.

Dr. Florin explored quantum concepts alongside traditional gate theories for how the body could make sense out of noisy signals. He hoped that someone might figure out how the 50-year old cocktail party effect might work at the quantum level. Perhaps some has. (1)

Dr. Florin tested nearly every observation with the “null” hypothesis. That is, that “PhotoMed’s therapy won’t work any better than previous attempts”. This method overcomes the bias of starting with a hypothesis.

He posited that the outcomes from PhotoMed’s therapy are not special from a biomechanical perspective.  He continued, if the photons have properties within the range from ordinary starlight to bright sunlight, then everything after that must be “not special” either.

But what did Dr. Florin’s “not special” mean?

Sadly, he passed away before the concept of the return back to normal function arrived. He might have said that was his intention when he repaired neurons.

Curiosity and CRPS

Dr. Florin found CRPS (complex regional pain syndrome) to be a “perfect storm” disorder. CRPS earned its “complex” rating for the many interacting systems involved. The interactions fascinated him. He wondered, how could a complex disorder vanish?

CRPS resists practically everything thrown at it. Blocking pain signals with surgeries, medications, or electrical stimulation provides relief for only some patients. For patients with abnormal skin temperatures, forced warming or cooling of affected body parts doesn’t reset the thermostat.

However, a few photons from PhotoMed’s therapy appeared to unstick some stuck process. He found that people responded most vigorously to PhotoMed’s therapy had not responded to other attempts. The disorders were the ones which later became known as “nothing worked” disorders. It appeared to him that patients with satisfactory relief from the other interventions did not respond as vigorously.

Before its popularity, he applied machine-learning techniques to avoid the bias of thinking that he knew how things work. The suggested that the real-time recordings held secrets. We just didn’t know them yet.

Could the warming trends of hands in the real-time recordings offer clues about the photon’s properties that prompted the event? What about the other symptoms and signs that appeared to disappear after skin temperature returned to comfortable responsiveness? If the pathophysiology resolves, isn’t that aging in reverse?

Dr. Florin followed trends in thinking about complex disorders. He followed the on-going work of a few researchers.

A prominent researcher of CRPS was Stephen Bruehl, PhD., who helped define the diagnostic criteria for CRPS. Dr. Bruehl’s papers suggest many reasons why the pain isn’t leaving anytime soon. (2)


Two figures from that paper give hints about the disorder’s complex pathophysiology.

Bruehl Pathophysiology Table 1.PNG
Bruehl Pathophysiology Figure 1.PNG

Dr. Florin wanted to learn how a few photons might prompt the collapse of the CRPS interacting systems and impaired functions. Real-time recordings only showed him changes in skin temperature. The rest was a mystery.


Citations

(1) https://journals.lww.com/pain/Fulltext/2019/05000/Chronic_pain_is_associated_with_a_brain_aging.14.aspx Chronic pain is associated with brain aging biomarker in community-dwelling older adults, PAIN: May 2019 - Volume 160 - Issue 5 - p 1119–1130  doi: 10.1097/j.pain.0000000000001491

(2) https://theconversation.com/how-do-brains-tune-in-to-one-neural-signal-out-of-billions-121016 How do brains tune in to one neural signal out of billions? Morgera SD, Univ of South Florida

(3) https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1933227  An Update on the Pathophysiology of Complex Regional Pain Syndrome. Stephen Bruehl, PhD. 2010 Anesthesiology 9 2010, Vol.113, 713-725. doi:10.1097/ALN.0b013e3181e3db38

 

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