­­­­­­­­­­­­­­­­What might the Instant Verification System find?

Warning: technical jargon ahead


For 18 years, PhotoMed’s team operated in stealth mode. The responses and outcomes to its therapy were not explained by conventional medical texts. They were too quick, too large, and frequently didn’t require additional therapy. The “back-to-normal” function applies to all of the disorders that have responded so far. What questions arise from that observation?

Could the seemingly endless process of “managing” states of a disorder suddenly end? See Figure 1.

Could the chronic state instantly switch to homeostasis? How long might that instant last?

Is it neuroplasticity on steroids? Quantum entanglement? Or, something so ordinary that it’s been overlooked?


Instant replay - will it change expectations?

PhotoMed’s Instant Verification System™ is like a video referee. It lets everybody re-examine and verify what happened and when. Someday, others may find out why and how.

From a physics perspective, wouldn’t you expect there to be an instant in time when the “chronic” state switches to homeostasis? Could that instant pass unnoticed by people who don’t have pain or impairments?

Figure 1  - The Instant Verification System helps the operator prompt and record physiological responses that may predict later benefit. Real-time data simplifies verification of unexpected outcomes. The System measures TIME in milliseconds for comparing details of events. Would “by-the-visit” granularity miss details of the patient’s return back-to-normal function?

Figure 1 - The Instant Verification System helps the operator prompt and record physiological responses that may predict later benefit. Real-time data simplifies verification of unexpected outcomes. The System measures TIME in milliseconds for comparing details of events. Would “by-the-visit” granularity miss details of the patient’s return back-to-normal function?

Treatment-resistant pain with no known bio-mechanical reason presents great challenges to conventional medicine that requires a target to shoot at. Could the definition of pain provide a target? Pain is “an unpleasant sensory and emotional experience…” according to the IASP (International Association for the Study of Pain).

Could there be a vacuum of experience after a chronic pain state concludes? Or, would you suddenly refer to your pain in the past tense?

Curiously, volunteers in PhotoMed’s studies frequently shifted from the “now” tense of their pain to the past tense of an ordinary memory. We didn’t notice this effect until examining recordings taken in real time. Could it be the same effect as when you find your lost keys?

Achieving and recording unexpected outcomes

“Maria” had experienced pain in the base of her left thumb for several years. Her thumb muscles were enlarged from their constant use in her job as a dental hygienist. She arrived with cold hands from being outside on a snowy day.

The aim was to relieve her pain by prompting a warming response. Therapy started (Tx1) with settings aimed to prompt a warming response. The operator didn’t notice any response. The second procedure (Tx2) was also selected for possible warming. Thermal imaging, via the veins turning dark (colder), showed a slow warming trend. The third procedure (Tx3) applied different wavelengths to the painful area.

Maria’s warming response suggested to the operator that she didn’t need more therapy for that visit. In fact, she did not need a second visit. Her pain remained low for over the year follow-up period. (Lighter gray is warmer - 11 seconds)

 

Figure 2 - Recordings like this helped PhotoMed’s engineering team develop the Triple 2 Algorithm.

What could the Instant Verification System do for your patients?

The Instant Verification System™ helps the physician verify that symptomatically impaired functions are improving.

The System tracks the steps taken to achieve results, or not.

The System lets the operator monitor and record electronic sensors as events unfold. For example, thermal imaging for abnormal skin temperatures or recording fresh exudates as they appear in wounds.

The operator also may use a variety of questionnaires and narrative entries to intermittently document progress and outcomes.

The hardware devices are sophisticated electronic sensors. The software does the heavy lifting by integrating data streams during recording. Playback automatically presents data from all sensors at its proper time.

Figure 3  - Could integrated software and hardware record details of events formerly thought by many to be impossible? PhotoMed’s team was skeptical of the early recordings for lack of their prediction in texts. The developed the Instant Verification System to capture the data the next time the weird event occurred. The System may save years and money for launching pioneering research. the real-time recordings may provide clues for starting paths.

Figure 3 - Could integrated software and hardware record details of events formerly thought by many to be impossible? PhotoMed’s team was skeptical of the early recordings for lack of their prediction in texts. The developed the Instant Verification System to capture the data the next time the weird event occurred. The System may save years and money for launching pioneering research. the real-time recordings may provide clues for starting paths.

 
 

 

Do I need the Instant Verification System?

No. You can implement the PhotoMed’s Triple 2 Algorithm using only the Vari-Chrome™ Pro.

The Instant Verification System™ does not give you different outcomes, but perhaps a bit more efficiently. Also, real-time recordings may change how you interact with people who doubt your stories. How many recordings would they like to see?

Thermal imaging

Thermal imaging provides visual feedback to the operator in real-time. This is important because the patient typically reports warming or pain relief too late for the operator to make during-visit decisions.

Examination of the recordings may provide what and when data. Analyses may follow methods from industries other than medicine. For example, synchronized bilateral responses suggest that all sensing and control functions may be operating normally. Where in the brain might the warming response be initiated? See Figure 4.

For the physician, the System documents responses and outcomes for the visit. The patient might appreciate seeing the precise millisecond when their impaired function began the return toward its default state. And, your patients with treatment-resistant pain don’t have to defend themselves from their disbelieving friends about the outcome of your procedures.

The System takes away some older patient’s predispositions that you are a miracle worker and saves you time by not having to explain which deity you are channeling.

Figure 4 -A middle-aged woman's persistently cold hands warm. The algorithm tested different wavelengths and other settings. All treatments were fully active and intended to prompt warming. This was her first visit. She later reported continuing comfort and better sleeping.

 

Thermal imaging provides continuous real-time data about skin temperature changes. Monitoring temperatures may be appropriate for patients with abnormal skin temperatures. Example,s as in Figure 4, of a constant offset in side-to-side temperatures provides information about the integrated operation of the sensing, vascular, and control systems.

Please contact PhotoMed’s team to explore research possibilities.

What thermal imaging and PhotoMed’s therapy are not

There are many reasons that the patient’s hands may be cold. Thermal imaging presents only skin temperatures and does NOT show pain or the reason for the coldness.

PhotoMed’s thermal imaging system is not for diagnosing disorders. The imaging provides feedback about abnormal skin temperatures, which hopefully begin to return to normal. The real-time non-contact sensing devices provide physiological information without interpretation.

The Vari-Chrome® Pro is a physical therapy device and is not intended to treat any disease or disorder. The return of homeostasis may be a physiological process managed by the body and self-maintained after therapy ends.

We use the description “back-to-normal” functions as an objectively measurable change-of-state. We don’t mean to be rude, but were nerdy engineers who don’t try to ascribe reasons for the things we observe. We build models that might help everyone objectively communicate ideas about what the heck might be going on.

For example, the disorder list assigns clinical diagnoses to their minimum sensory, motor, thermoregulatory definitions. The list includes on disorders that responded during the first or second visit.

PhotoMed’s therapy aims to limit photonic energy at any wavelength to that delivered to the skin by direct sunlight sunlight. This is why PhotoMed’s therapy is called “non-invasive”. The aim is to let the skin do its sensing as it ordinarily does. This is important. PhotoMed’s therapy does NOT depend on “penetration” of the skin to prompt most its effects. Our team sponsored a study to test the need for red wavelengths for relieving diabetic neuropathy pain. Click here to see the results of the study.

We don’t know how “back-to-normal” works. “Normal” simply means that improved functions persist after therapy ends. Some call that homeostasis.

Video Camera

The Instant Verification System™ video camera interface (USB) provides for continuous or intermittent recordings during the visit with patient consent.

The recordings are temporally aligned with thermal imaging and the wavelength being output from the Vari-Chrome® Pro.

For example, would you like to show your patient’s:

  • “Thawing” of their “frozen” shoulder that takes place in minutes, not hours?

  • return of sensation in numb fingers or feet during a visit?

During replay, you may notice a flinch, a gasp, or spontaneous remark at the precise moment when the response begins.

Wound camera

The hi-def wound camera documents previously unseen phenomena in non-healing wounds that occur during the first few minutes of therapy. The operator can choose to take images or record longer periods.

Note that the wound camera generates massive loss-less compressed data files when recording at full frame rate.

Playback aligns temporal data from the USB camera, Vari-Chrome® Pro wavelength data, and the output from the 14-bit mono-chrome sensor. The aim is to document possible fresh exudates entering the wound during the visit.

In PhotoMed’s studies, fresh exudates in moist wounds frequently became visible within the first few minutes of therapy. Some exudates appeared dark at wavelengths shorter than about 600nm. Other exudates remained as clear fluids observable by their glistening surface. Of course, healing may restart without signs of fresh exudates. Counter-intuitively, very clean wounds do not appear to respond as vigorously as wounds with bio-films based on a small sample.

Link to Fresh-Exudates page.

Playback of recordings flexibly lets the examiner adjust parameters to observe details that might have otherwise been lost forever using a lower resolution camera. Integration with the USB (overall view) camera provides context for the observation of unexpected phenomena. The thermal imaging in this example was out of focus and ignored by our team as they focused on testing the System’s hardware and software.

Figure 5 -  De-identified screen shot of the replay module. The Instant Verification System includes proprietary innovations, such as the presentation of the wavelength emitted by the Vari-Chrome Pro on the time bar. The regular patterns show the wavelength automatically varying across a limited range of wavelengths.  This is a screen shot taken when the wavelength was manually adjusted to 460nm. The “In” and “Out” show the time range for export of images from the wound camera or thermal imaging camera. Wavelength data is exported as a caption that may later be turned on or off.

Figure 5 - De-identified screen shot of the replay module. The Instant Verification System includes proprietary innovations, such as the presentation of the wavelength emitted by the Vari-Chrome Pro on the time bar. The regular patterns show the wavelength automatically varying across a limited range of wavelengths. This is a screen shot taken when the wavelength was manually adjusted to 460nm. The “In” and “Out” show the time range for export of images from the wound camera or thermal imaging camera. Wavelength data is exported as a caption that may later be turned on or off.

Post-processing of real-time recordings may provide an economical means for possibly answering new questions without the expense and time to re-run an experiment. The recordings may save time and money launching new studies.

 

Questionnaires and narrative entry

The Instant Verification System™ supports standalone studies in small clinics. Real-time recordings from case studies (called n-of-1 studies) include physiological response data for later examination. The System tracks multiple sites of impaired functions and pain in parallel.

The operator can enter narratives and simultaneous tracking of multiple sites of pain during each visit. Because the algorithm is efficient, the system helps the operator resolve (hopefully) more than one source of pain during each visit.

Research tools for pioneers

Data from PhotoMed’s empirical data helped the team refine its Triple 2 Algorithm. The real-time recordings suggest new areas of research. Could the Instant Verification System™ save you time and money getting your research project started?

Figure 4  - schematic of data recorded in real-time by the Instant Verification System.

Figure 4 - schematic of data recorded in real-time by the Instant Verification System.

 

Each of the 500+ volunteers contributed a matrix of data. Different from studies that examine “managed” level of pain, TIME is a key to discovering possible relationships among multiple impairments. For example, back pain and loss of sensation in feet may be independent when each resolves at a different time.

What might AI and deep-learning discover in the data collected for developing the Triple 2 Algorithm?

Researchers: Could PhotoMed’s empirical data provides you with head start?

Like the early images from the Hubble Space Telescope, PhotoMed’s empirical data provide a baseline for comparing future data. The recordings were made without knowing what questions might be asked in the future. It is the first data from testing different wavelengths in the same person during each visit. The recordings include the timing of responses for apparently disparate disorders.

We’ll share some of PhotoMed’s empirical data with practitioners and researchers who use the Vari-Chrome® Pro or the Instant Verification System™.

Could PhotoMed’s real-time recordings spark the imaginations of physiologists, neuroscientists, and other specialties?

Here are few questions:

  • What do the mapping errors upon the return of normal sensation suggest about phantom and post-surgical pain?

  • Could the loss of sensation associated with diabetes be “learned non-awareness” like putting your hand cold water?

  • Could the therapy accelerate the recovery from “learned non-use” after stroke or spinal cord injury?

  • What might brain imaging find at the intersection between “chronic” and “normal”?

  • Where in the brain does the control function emanate for bi-lateral warming, restored sensations, and relieved pain?

  • Could the effects of neurological disorders, such as Huntington’s disease, be temporarily reduced and possibly slowed?

  • Could non-invasive therapies provide a new “experience” that allows a stuck experience to conclude?

  • Could the responses be to quick for neuroplasticity? How about for quantum entanglement?

Link to disorders listing